Asus PRIME X399-A w/ DDR4 2666, 7.1 Audio, Dual M.2, U.2, Gigabit LAN, 3-Way Crossfire / SLI

MX68048 PRIME X399-A w/ DDR4 2666, 7.1 Audio, Dual M.2, U.2, Gigabit LAN, 3-Way Crossfire / SLI
MX68048 PRIME X399-A w/ DDR4 2666, 7.1 Audio, Dual M.2, U.2, Gigabit LAN, 3-Way Crossfire / SLI MX68048 PRIME X399-A w/ DDR4 2666, 7.1 Audio, Dual M.2, U.2, Gigabit LAN, 3-Way Crossfire / SLI MX68048 PRIME X399-A w/ DDR4 2666, 7.1 Audio, Dual M.2, U.2, Gigabit LAN, 3-Way Crossfire / SLI

Product Info

ASUS Prime X399-A EATX Motherboard For AMD® Threadripper™


featureASUS announces the Prime X399-A EATX Gaming Motherboard for AMD® Threadripper™ CPUs with the latest features: M.2 Heatsink, DDR4-3600 (OC), Dual M.2 Slots, U.2 Slot, 3-Way CrossFire / SLI Modes and USB 3.1 Type C and A Gen2 ports.

The ASUS PRIME X399-A is the prime choice for prosumers and content creators featuring 1-click overclocking with 5-Way Optimization, ASUS Pro Clock Technology, and multiple GPU support with SafeSlot protection. Dual M.2 and front-panel USB 3.1 deliver optimized data speeds, while AURA Sync lighting and 3D-printing mounts provide unlimited personalization.

AMD® Threadripper™ CPUs Are For Serious Gamers & Workstations

featureThis Prime X399-A Motherboard only fits AMD® Ryzen™ Threadripper™ Processors and is designed for Serious Gamers and Extreme Workstation Users who can take full advantage of up to 16 Cores and 32 Threads.

You also get to use the latest I/O Technologies like 3-Way or 2-Way SLI / CrossFire Video Card setups, up to 3x M.2 / U.2 Storage Cards and USB 3.1 enabled external devices.

Are You Ready For Prime Video Game Graphics?

New AMD® TR4 Socket Threadripper™ Processors have an incredible 64x PCIe 3.0 Lanes so you can run up to 3 High End Video Cards at once for the very best graphics at 4K UHD or beyond on Multiple Monitors! You still have enough PCIe Lanes left over to run 2x M.2 PCIe 3.0 x4 cards and also an U.2 card at full speed.

Here is how SLI and CrossFire Video Cards configure on this Motherboard:

  • 3 Video Card: x16 / x16 / x8
  • 2 Video Card: x16 / x16
  • 1 Video Card: x16



  • Ready For AMD® Socket TR4 THREADRIPPER™ Processors
  • 5-Way Optimization:
    One-click, system-wide tuning, delivering optimized overclocks and intelligent cooling for CPU or GPU-intensive tasks
  • Industry Leading Cooling Options:
    Comprehensive controls for fans and water pumps, via Fan Xpert 4 software or the acclaimed ASUS UEFI
  • Next Gen Connectivity:
    Onboard U.2, Dual M.2 and front-panel USB 3.1 Gen2 (10Gbps) connectors
  • M.2 Card Heatsink:
    Ultra-efficient heatsink lowers M.2 SSD temps by up to 20° C for unthrottled transfer speeds and enhanced reliability
  • Aura Sync:
    Controllable onboard RGB lighting easily syncs with an ever-growing portfolio of Aura Sync-capable hardware.

Additional Information:

Visit the Manufacturer Web Page for Full Details

System Requirements

PC with:

  • CPU: AMD® Socket TR4 Threadripper™
  • Video Card: Requires at least one PCIe Video Card


CPU Support For Socket TR4 AMD® Ryzen™ Threadripper™ Processors
Chipset AMD® X399 Chipset
Memory 8x DIMM DDR4-2666 RAM Slots, Quad Channel Memory
Supports OC RAM up to DDR4-3600
128GB Max RAM (8x 16GB)
Integrated Graphics AMD® Threadripper™ CPUs do not have Integrated Graphics

At least 1x PCIe 2.0+ Video Card is required

Storage AMD® X399 Chipset:
6x SATA 6Gb/s ports
SATA ports support RAID 0, 1 & 10

AMD® Ryzen™ Threadripper™ Processor:
1x M.2 Socket 3, w/ M key, type 2242, 2260, 2280, 22110
(PCIE 3.0 x4 or SATA III)
1x M.2 Socket 3, w/ M key, type 2242, 2260, 2280
(PCIE 3.0 x4 or SATA III)
1x U.2 Card Slot

Expansion Slots 4x PCIe 3.0 x16 Slots
(Supports up to 3x PCIe 3.0 Video Cards)
1x PCIe 2.0 x4 Slot
1x PCIe 2.0 x1 Slot
Multi-GPU Support Supports up to 3-Way NVIDIA® SLI™ Technology
Supports up to 3-Way AMD® CrossFire™ Technology

3-Way Graphics Card Mode: x16 / x16 / x8
2-Way Graphics Card Mode: x16 / x16
1-Way Graphics Card Mode: x16

USB Ports ASMedia® USB 3.1 Gen2 (10Gbps) Controller:
1x USB 3.1 Gen2 Type-C (10Gbps) port
1x USB 3.1 Gen2 Type-A (10Gbps) port

AMD® Ryzen™ Threadripper™ Processor:
8x USB 3.1 Type-A Gen1 (5Gbps) ports at back panel

AMD® X399 Chipset:
1x USB 3.1 Gen2 (10Gbps) port (mid-board)
4x USB 3.1 Gen1 (5Gbps) ports (mid-board)
4x USB 2.0 (480Mbps) ports (mid-board)
LAN Intel® I211-AT chipset:
1x Gigabit LAN RJ45 port
ASUS Turbo LAN Utility
Wi-Fi N/A
Bluetooth® N/A
Audio Realtek® ALC S1220A 8-Channel HD Codec:
Crystal Sound 3

Internal audio Amplifier to enhance the highest quality sound for headphone and speakers
Impedance sense for front and rear headphone outputs
Jack-detection w/ Multi-streaming
Front Panel Jack-retasking

High Fidelity I/O ports:
High quality 120dB Line-out
Input SNR: 113 dB Recording Line-in
Audio Features DTS Connect & DTS Headphone:X
Optical S/PDIF out port on back panel
Audio Shielding: Ensures precision analog/digital separation and greatly reduced multi-lateral interference
Dedicated audio PCB layers: Separate layers for left and right channels to guard the quality of the sensitive audio signals
Premium Japanese-made audio capacitors: Provide warm, natural and immersive sound with exceptional clarity and fidelity
Unique de-pop circuit: Reduces start-up popping noise to audio outputs
EMI protection cover to prevent electrical noise to affect the amplifier quality
Separate layer for left and right track, ensuring both sound deliver equal quality
Back Panel I/O Ports 1x USB 3.1 Type-C Gen2 (10Gbps) port
1x USB 3.1 Type-A Gen2 (10Gbps) port
8x USB 3.1 Gen 1 (5Gbps)
1x Gigabit LAN (RJ45) port
5x 3.5mm Audio jacks
1x Optical S/PDIF out
1x USB BIOS Flashback Button
Internal I/O Connectors 1x 3-pin Cover fan (COV_FAN) connector
1x Q_Code
2x RGB Headers
2x USB 3.1 Gen 1 Type A connectors make 4x USB 3.1 Gen1 ports
2x USB 2.0 connectors make 4x USB 2.0 ports
1x M.2 Socket 3 with M key, type 2242/2260/2280 storage devices support (SATA & PCIE 3.0 x 4 mode)
1x M.2 Socket 3 with M key, type 2242/2260/2280/22110 storage devices support (SATA & PCIE 3.0 x 4 mode)
1x M.2_FAN connector
1x U.2 port
6x SATA 6Gb/s connectors
1x USB 3.1 Gen 2 front panel connector
1x CPU Fan connector
1x CPU OPT Fan connector
3x Chassis Fan connectors
1x AIO_PUMP connector
1x W_PUMP+ connector
1x 24-pin EATX Power connector
1x 8-pin ATX 12V Power connector
1x 4-pin ATX 12V Power connector
1x Front panel audio connector (AAFP)
1x System panel
1x 5-pin EXT_FAN(Extension Fan) connector
1x Thermal sensor connector
1x Power-on button
1x Clear CMOS button
Special Features OC Design:
ASUS PRO Clock Technology
Full BCLK range for extreme overclocking performance

ASUS Dual Intelligent Processors 5-Way Optimization by Dual Intelligent Processors 5:
5-Way Optimization tuning key perfectly consolidates TPU, EPU, DIGI+ VRM, Fan Expert 4, and Turbo App

Aura RGB Strip Headers
Aura Lighting Effects Synchronization with compatible ASUS ROG devices

ASUS Exclusive Features:
USB BIOS Flashback
AI Suite 3
Ai Charger
Onboard Button: Power
ASUS UEFI BIOS EZ Mode featuring friendly graphics user interface
Turbo LAN
Crystal Sound 3
PC Cleaner

ASUS Quiet Thermal Solution:
Stylish Design Heat-pipe solution
Stylish Fanless Design with M.2 Heat-sink solution
ASUS Fan Xpert 4

ASUS EZ Flash 3
Multi-language BIOS

ASUS Q-Design:
ASUS Q-Shield
ASUS Q-Connector

Gaming Aesthetics:
3D printing friendly
AURA-RGB Lighting

M.2 and U.2 Onboard (The Latest Transfer Technology with up to 32Gb/s Data-transfer Speeds for M.2 and U.2)
BIOS 128 Mb Flash ROM, UEFI AMI BIOS, PnP, WfM2.0, SM BIOS 3.0, ACPI 6.1, Multi-language BIOS, ASUS EZ Flash 3, CrashFree BIOS 3, F11 EZ Tuning Wizard, F6 Qfan Control, F3 My Favorites, Last Modified log, F12 PrintScreen and ASUS DRAM SPD (Serial Presence Detect) memory information
Manageability WfM 2.0, DMI 3.0, WOL by PME, PXE
Operating System Requires Windows® 10, 64 bit.
Other Operating Systems not supported
Form Factor EATX Form Factor: 305 x 269mm
Weight N/A

Package Contents

  • ASUS Prime X399-A EATX Motherboard
  • User's Manual
  • ASUS Q-Shield
  • 4x SATA 6Gb/s cables
  • 1x Vertical M.2 bracket set
  • 1x M.2 Screw Package
  • 1x Supporting DVD
  • 1x SLI HB BRIDGE (2-Way M)
  • 1x Q-Connector